Abstract: Melanoma brain metastases (MBM) are associated with poor prognosis and remain a significant challenge in oncology. In recent years, significant progress has been made in understanding the molecular mechanisms underlying MBM. Advances in targeted therapies, immunotherapies, and stereotactic radiosurgery (SRS) have significantly improved patient survival. This study presents an overview of the current landscape of treatment approaches and emerging modalities for MBM treatment, highlighting recent advancements and future directions for research and clinical practice.