From Stabilization to Depletion: Molecular Imaging to Measure Therapeutic Response in ATTR-CA

Transthyretin cardiac amyloidosis (ATTR-CA) is marked by deposition of transthyretin amyloidosis (ATTR) fibrils within the myocardium leading to increased myocardial stiffness and heart failure. Without treatment, ATTR-CA results in progressive heart failure with a 50% mortality rate within 5 y ([1