生物
繁殖
秀丽隐杆线虫
功能(生物学)
G蛋白偶联受体
细胞生物学
遗传学
基因
受体
作者
Daniel Matúš,Wilbert Post,Victoria Elisabeth Groß,Alexander Bernd Knierim,Christina Katharina Kuhn,Franziska Fiedler,Darian Benno Tietgen,Johanna Lena Schön,Torsten Schöneberg,Simone Prömel
标识
DOI:10.1093/g3journal/jkae206
摘要
Adhesion G protein-coupled receptors (aGPCR) are unique molecules. They are able to transmit classical signals via G-protein activation as well as mediate functions solely through their extracellular N termini, completely independently of the seven transmembrane helices domain (7TM) and the C terminus. This dual mode of action is highly unusual for GPCRs and allows for a plethora of possible cellular consequences. However, the physiological implications and molecular details of this N terminus-mediated signaling are poorly understood. Here, we show that several distinct 7TM-independent/trans functions of the aGPCR Latrophilin homolog LAT-1 in the nematode Caenorhabditis elegans together regulate reproduction: sperm guidance, ovulation, and germ cell apoptosis. In these contexts, the receptor elicits its functions in a non-cell autonomous manner. The functions might be realized through alternative splicing of the receptor specifically generating N terminus-only variants. Thus, our findings shed light on the versatility of 7TM-independent/N terminus-only/trans functions of aGPCR and discuss possible molecular details.
科研通智能强力驱动
Strongly Powered by AbleSci AI