糖尿病
2型糖尿病
疾病
肾脏疾病
全基因组关联研究
医学
糖尿病肾病
遗传关联
生物信息学
生物
遗传学
内科学
基因型
单核苷酸多态性
内分泌学
基因
作者
Binura Taurbekova,Kymbat Mukhtarova,Zhandos Salpynov,Joseph U. Almazan,Kuralay Atageldiyeva,Antonio Sarría‐Santamera
标识
DOI:10.2174/0109298673328801241015165257
摘要
Diabetic kidney disease is a devastating diabetic complication, affecting up to half of people suffering from diabetes. The global burden of diabetic kidney disease is steadily increasing worldwide along with the growing prevalence of type 2 diabetes. The epidemic rise of type 2 diabetes is primarily observed in Asia, including the East Asian regions. It is generally accepted that heredity is one of the main determinants in the pathogenesis of diabetic kidney disease. Since the advent of genome-wide association studies, numerous studies have been published to identify the genetic loci susceptible to diabetic kidney disease among diverse populations. Although genome-wide association studies exploring diabetic kidney disease susceptibility loci have focused primarily on populations of European descent, a number of novel genetic variants associated with diabetic kidney disease have also been successfully revealed among East Asians. A comprehensive analysis of the genetic architecture and pathophysiological pathways of diabetic kidney disease may allow the identification of new potential therapeutic targets. This review aimed to summarize genome-wide association studies examining genetic variants associated with diabetic kidney disease in the populations of East Asian ancestry with type 2 diabetes and presented our perspective on the future of this field.
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