Intracranial pulse pressure amplitude as an indicator of intracranial compliance: observations in symptomatic children with Chiari malformation type I

医学 颅内压 核医学 放射性武器 放射科
作者
Radek Frič,Eline Bryne,Bogna Warsza,Per Kristian Eide
出处
期刊:Journal of neurosurgery [Journal of Neurosurgery Publishing Group]
卷期号:: 1-8
标识
DOI:10.3171/2024.4.peds24168
摘要

OBJECTIVE Reduced intracranial compliance (ICC) may be an important factor in the pathophysiology of Chiari malformation type I (CM-I). However, direct measurement of ICC is controversial because of its invasiveness, particularly in children. Instead, ICC may be estimated from continuous measurements of intracranial pressure (ICP), where the metric mean wave amplitude (MWA) has been found to be more useful as a surrogate marker of ICC than mean ICP. This observational study investigated the distribution of MWA and mean ICP in symptomatic children with CM-I, as well as their association with clinical and radiological findings. METHODS From a consecutive series of children treated for CM-I at a single institution between 2006 and 2023, the authors analyzed ICP scores in those who underwent an overnight preoperative ICP recording in which MWA was calculated. Clinical and radiological data were retrieved from the patient records. RESULTS Thirty-seven children (mean age 12.4 ± 3.6 years) with symptomatic CM-I were identified. From the overnight ICP measurements, the average MWA was 5.2 ± 1.3 mm Hg: 56% of children had an abnormal MWA (> 5 mm Hg) and 33% had a borderline MWA (4–5 mm Hg). In contrast, the average mean ICP was 9.7 ± 4.1 mm Hg: 8% of children had an abnormal mean ICP (> 15 mm Hg) and 41% had a borderline mean ICP (10–15 mm Hg). Thus, more children were found to have an abnormal MWA than an abnormal mean ICP (p < 0.001). MWA was significantly higher in the subgroup of children with medullary compression in the foramen magnum, as seen on MRI, than in those without (5.6 ± 1.0 mm Hg vs 4.7 ± 1.4 mm Hg, p = 0.03), whereas a similar difference was not observed for mean ICP (9.9 ± 4.6 mm Hg vs 9.7 ± 3.7 mm Hg, p = 0.889). CONCLUSIONS In this cohort of symptomatic children with CM-I, MWA was more frequently abnormal than mean ICP, with a clinically significant discrepancy in half of the patients. Moreover, MWA was significantly higher in patients with medullary compression. Based on these findings, the authors’ interpretation is that in children with CM-I, the ICC may be reduced, as indicated by increased MWA, even though the mean ICP is within normal thresholds.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Star完成签到,获得积分10
1秒前
1秒前
柔弱的不二完成签到,获得积分10
2秒前
无心的枫完成签到,获得积分10
4秒前
djdh完成签到 ,获得积分10
4秒前
肖果完成签到 ,获得积分10
7秒前
哭泣笑柳发布了新的文献求助10
8秒前
CipherSage应助长安采纳,获得10
9秒前
飒飒完成签到,获得积分10
10秒前
RONG完成签到 ,获得积分10
10秒前
落落完成签到,获得积分10
11秒前
Yan完成签到 ,获得积分10
12秒前
12秒前
谨慎的凝丝完成签到 ,获得积分10
13秒前
雨洋完成签到,获得积分10
14秒前
chi完成签到 ,获得积分10
15秒前
还单身的湘完成签到,获得积分10
17秒前
fyjlfy完成签到 ,获得积分10
17秒前
深情安青应助Nayvue采纳,获得10
18秒前
研友_Y59785完成签到,获得积分0
18秒前
Xiaoxiao发布了新的文献求助10
19秒前
初初见你完成签到,获得积分10
26秒前
29秒前
思源应助淡淡月饼采纳,获得20
29秒前
dd完成签到 ,获得积分10
30秒前
Nayvue发布了新的文献求助10
34秒前
未来的幻想完成签到,获得积分10
36秒前
Kvolu29完成签到,获得积分10
37秒前
长理物电强完成签到,获得积分10
38秒前
若安在完成签到,获得积分10
39秒前
完美世界应助潘特采纳,获得10
40秒前
拼搏问薇完成签到 ,获得积分10
40秒前
单薄乐珍完成签到 ,获得积分0
43秒前
张静枝完成签到 ,获得积分10
43秒前
六步郎完成签到,获得积分10
43秒前
啊怙纲完成签到 ,获得积分10
45秒前
量子星尘发布了新的文献求助10
47秒前
scott_zip完成签到 ,获得积分10
48秒前
gxl完成签到,获得积分0
52秒前
xxx完成签到 ,获得积分10
55秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022