过氧亚硝酸盐
纳米技术
荧光
机制(生物学)
化学
生物物理学
材料科学
生物
生物化学
物理
哲学
认识论
量子力学
酶
超氧化物
作者
Jiarao Sun,Xiaoli Cao,Wenjuan Lu,Yongchun Wei,Lingxiu Kong,Wei Chen,Xintian Shao,Yan‐Feng Wang
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2023-01-01
卷期号:13 (5): 1716-1744
被引量:30
摘要
Peroxynitrite (ONOO-), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO- at the cellular level is of great significance to understand its pathogenesis. To this end, a variety of fluorescent probes based on small molecules and nanoparticles (NPs) have been engineered and applied as excellent tools for imaging of ONOO- in cells as well as in their diverse biological applications. In this review, we highlight representative cases of fluorescent probes based on recognition mechanism and emphasize their response type (ratiometric, two-photon, long-wavelength/near-infrared, and targeting) in ONOO- detection in the last five years. We further discuss their design strategy, sensing mechanism, and application in bio-imaging and describe NP-based probes according to diverse nanoplatforms.
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