抗原
免疫系统
CD8型
生物
信使核糖核酸
癌症研究
免疫学
癌症疫苗
免疫疗法
病毒学
基因
生物化学
作者
Xiaoxuan Li,Huiyan Wang,Wujiang Lai,Jinrong Liao,Wenyu Mo,Keke Huang,Liqing He,Xiaomei Liang,Zhibin Yu,Jiang Xu,Xian-Wu Hua,Fujun Hou,Jun Ding,William Jia,Kuan Zhang,Yifeng Wang
出处
期刊:Immunology
[Wiley]
日期:2024-03-12
卷期号:172 (3): 375-391
被引量:6
摘要
Persistent human papillomavirus (HPV) infection is associated with multiple malignancies. Developing therapeutic vaccines to eliminate HPV-infected and malignant cells holds significant value. In this study, we introduced a lipid nanoparticle encapsulated mRNA vaccine expressing tHA-mE7-mE6. Mutations were introduced into E6 and E7 of HPV to eliminate their tumourigenicity. A truncated influenza haemagglutinin protein (tHA), which binds to the CD209 receptor on the surface of dendritic cells (DCs), was fused with mE7-mE6 in order to allow efficient uptake of antigen by antigen presenting cells. The tHA-mE7-mE6 (mRNA) showed higher therapeutic efficacy than mE7-mE6 (mRNA) in an E6 and E7
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