免疫组织化学
生物
外显子
连环素
病理
间质细胞瘤
间质细胞
间质细胞
支持细胞
癌症研究
医学
基因
Wnt信号通路
遗传学
内分泌学
精子发生
促黄体激素
激素
作者
Yukiko Kitagawa,Dario de Biase,Costantino Ricci,Kristine M. Cornejo,Michelangelo Fiorentino,Katrina Collins,Muhammad T. Idrees,Maurizio Colecchia,Thomas M. Ulbright,Andrés Acosta
摘要
Testicular Leydig cell tumours (LCTs) are the most common type of sex cord-stromal tumour in men, representing 1%-3% of all testicular neoplasms. Among testicular sex cord-stromal tumours, CTNNB1 mutations and nuclear expression of β-catenin have been typically associated with Sertoli cell tumour. Recent genomic analyses have shown that CTNNB1 variants are also identified in a subset of LCTs; however, the frequency and clinicopathologic associations of β-catenin alterations remain incompletely understood in this tumour type.
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