Applications of Nanomedicine in Animal Models of Cancer

Cancer is one of the foremost causes of death worldwide, and advanced therapeutics are desperately required. The progress of new nanocarriers and nanomaterials has resulted in significant advancements in cancer drug delivery. Most nanocarrier uses have had the primary goal of protecting the drug from rapid degradation systemic distribution and allowing it to reach therapeutic concentrations at tumor sites, while avoiding drug delivery to regular locations as much as possible to limit unwanted effects. Scientists now have new techniques for treating and imaging cancer thanks to breakthroughs in nanotechnology. This approach has enabled nanoscale devices to be merged with numerous functional molecules simultaneously, such as antibodies, tumor-specific ligands, imaging probes, and cancer treatments. Because structural and physical factors such as size, load, shape, and surface features affect drug biodistribution, pharmacokinetics, internalization, and security, rational nanoparticle design is crucial. Because traditional cancer therapies have limitations, various nanotechnologies for more effective and safer cancer treatment, also known as cancer nanomedicine, have been developed and applied. This chapter discusses cancer advancements, challenges, and opportunities in animal models for cancer management with nanomedicine.