接口
生物医学工程
心肌梗塞
心脏电生理学
医学
计算机科学
心脏病学
电生理学
内科学
计算机硬件
作者
Zhiyuan Chen,Zexu Lin,Sofian N. Obaid,Eric Rytkin,Sharon A. George,Christopher Bach,Micah Madrid,Miya Liu,Jessica LaPaino,Amy Fehr,Xinyu Shi,Nathaniel Quirion,Benjamin Russo,Helen S Knight,Anthony Aduwari,Igor R. Efimov,Luyao Lu
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-07-07
卷期号:9 (27)
标识
DOI:10.1126/sciadv.adi0757
摘要
Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement.
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