Hydrogen energy has the potential to be a cost-effective and strong technology for brighter development. Hydrogen fuel production by water electrolyzers has attracted attention. 2D nanocomposites with distinctive properties have been extensively explored for various applications from hydrogen evolution reactions to improving the efficiency of water electrolyzer, which is the most eco-friendly, and high-performance for hydrogen production. Recently, typical 2D nanocomposites such as Metal-Free 2D, TMDs, Mxene, LDH, organic composites, and Heterostructure have recently been thoroughly researched for use in the HER. We discuss effective ways for increasing the HER efficiency of 2D catalysts in this paper, And the unique advantages and mechanisms for specific applications are highlighted. Several essential regulating strategies for developing 2D nanocomposite-based HER electrocatalysts are included such as interface engineering, defect engineering, heteroatom doping, strain & phase engineering, and hybridizing which improve HER kinetics, the electrical conductivity, accessibility to catalytic active sites, and reaction energy barrier can be optimized. Finally, the future prospects for 2D nanocomposites in HER are discussed, as well as a thorough overview of a variety of methodologies for designing 2D nanocomposites as HER electrocatalysts with excellent catalytic performance. We expect that this review will provide a thorough overview of 2D nanocatalysts for hydrogen production.