Response by Tang et al to Letter Regarding Article, “Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy”

HomeCirculationVol. 148, No. 24Response by Tang et al to Letter Regarding Article, "Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy" No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextResponse by Tang et al to Letter Regarding Article, "Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy" Yansong Tang, Mengying Feng, Dachun Xu and Ke Wei Yansong TangYansong Tang https://orcid.org/0000-0002-8768-8498 Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, China (Y.T., M.F., K.W.). , Mengying FengMengying Feng Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, China (Y.T., M.F., K.W.). , Dachun XuDachun Xu https://orcid.org/0000-0002-4123-6613 Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.X.). and Ke WeiKe Wei https://orcid.org/0000-0001-8542-2146 Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, China (Y.T., M.F., K.W.). Originally published11 Dec 2023https://doi.org/10.1161/CIRCULATIONAHA.123.066937Circulation. 2023;148:1980–1981"Response by Tang et al to Letter Regarding Article, "Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy"." Circulation, 148(24), pp. 1980–1981FootnotesCirculation is available at www.ahajournals.org/journal/circREFERENCES1. Oh S, Shin S, Janknecht R. The small members of the JMJD protein family: enzymatic jewels or jinxes?Biochim Biophys Acta Rev Cancer. 2019; 1871:406–418. doi: 10.1016/j.bbcan.2019.04.002CrossrefMedlineGoogle Scholar2. Tang Y, Feng M, Su Y, Ma T, Zhang H, Wu H, Wang X, Shi S, Zhang Y, Xu Y, et al. Jmjd4 facilitates Pkm2 degradation in cardiomyocytes and is protective against dilated cardiomyopathy.Circulation. 2023; 147:1684–1704. doi: 10.1161/CIRCULATIONAHA.123.064121LinkGoogle Scholar3. Ni L, Lin B, Hu L, Zhang R, Fu F, Shen M, Yang J, Shi D. Pyruvate kinase M2 protects heart from pressure overload-induced heart failure by phosphorylating RAC1.J Am Heart Assoc. 2022; 11:e024854. doi: 10.1161/JAHA.121.024854LinkGoogle Scholar4. Li Q, Li C, Elnwasany A, Sharma G, An YA, Zhang G, Elhelaly WM, Lin J, Gong Y, Chen G, et al. PKM1 exerts critical roles in cardiac remodeling under pressure overload in the heart.Circulation. 2021; 144:712–727. doi: 10.1161/CIRCULATIONAHA.121.054885LinkGoogle Scholar5. Magadum A, Singh N, Kurian AA, Munir I, Mehmood T, Brown K, Sharkar MTK, Chepurko E, Sassi Y, Oh JG, et al. Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration.Circulation. 2020; 141:1249–1265. doi: 10.1161/CIRCULATIONAHA.119.043067LinkGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails December 12, 2023Vol 148, Issue 24 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.066937PMID: 38079487 Originally publishedDecember 11, 2023 PDF download Advertisement