微气泡
血栓形成
血小板
医学
模态(人机交互)
血小板活化
内科学
放射科
超声波
计算机科学
人工智能
作者
Yabin Wang,Yang Zhang,Ning Yang,Qian Zhang,Sai Ma,Mengqi Xu,Yunxue Xu,Shan Gao,Yan Fang,Na Li,Sulei Li,Ping Liang,Xu Zhang,Li Fan,Feng Cao
摘要
Abstract Background Acute thrombotic events play a major role in various cardiovascular diseases. Therefore, direct thrombus imaging can be proved beneficial for early diagnosis and prompt therapy of thrombosis. Our study investigated targeted dual‐modality cyclic arginine‐glycine‐aspartic micro bubbles (cRGD‐MBs) for direct imaging of thrombi by fluorescence and ultrasound. Methods cRGD‐MBs were prepared by mechanical vibration and chemical chelation methods. Results Coulter counter analysis demonstrated that the cRGD‐MBs were well dispersed, with diameters ranging from 1 to 3 μm. They emitted bright red fluorescence under an excitation wavelength of 660 nm. In vivo fluorescence and ultrasound imaging revealed that cRGD‐MBs accumulated at the site of thrombus in the carotid artery with significant fluorescence and ultrasonic signal. Conclusions This study showed that novel microbubble cRGD‐MBs were successfully synthesized, and that these could potentially be used as contrast agents for immediate diagnosis of acute thrombus in vivo.
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