Tissue and Cell Dual‐Penetrating Dendritic Lipopeptide Liposomes for Hypertrophic Scar Treatment

Abstract Hypertrophic scar is a complex global disease, which can lead to remarkable functional impairment, pruritus, and pain. Treating local skin diseases needs a transdermal drug delivery system that can simultaneously promote cell and tissue penetration within the hypertrophic scar. Herein, a tissue and cell dual‐penetrating liposomal delivery platform consisting of arginine‐based dendritic lipopeptide mimicking the pivotal amino acid sequence in viral protein transduction domains and virion‐like nanostructure to enhance hypertrophic scar tissue deep penetration and cellular internalization is reported. This dendritic lipopeptide liposomal delivery platform can overcome corneum barriers to the punch on hypertrophic scar fibroblast membranes, as are natural viruses. It also can deeply deliver drugs to promote hypertrophic scar fibroblast apoptosis and collagen fiber remodeling within thickened dermis and epidermis, and finally remove the raised scars.