核仁
荧光
染色体易位
线粒体
化学
生物物理学
线粒体DNA
细胞内
细胞生物学
分子生物学
生物
生物化学
物理
细胞质
光学
基因
作者
Chi Li,Chong Zong,Yang Liu,Zhiqiang Liu,Kang‐Nan Wang,Xiaoqiang Yu
标识
DOI:10.1016/j.cclet.2023.108323
摘要
Mitochondrial damage is closely related to the occurrence of many diseases. However, accurate monitoring and reporting of mitochondrial damage are not easy. Here, we developed a small molecule fluorescent probe named CB-Cl, which has splendid spectral properties (large Stokes shift, strong affinity for RNA, etc.) and excellent targeting ability to intracellular mitochondria. After mitochondria were damaged by external stimuli, CB-Cl would light up the nucleolus as a signal reporter. The cascade imaging of mitochondria and nucleolus using CB-Cl can monitor and visualize the mitochondrial status in living cells in real-time. Based on the above advantages, the probe CB-Cl has reference significance for the related research of mitochondrial damage and the prevention and treatment of related diseases.
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