Rosuvastatin versus atorvastatin treatment in adults with coronary artery disease: secondary analysis of the randomised LODESTAR trial

医学 瑞舒伐他汀 阿托伐他汀 危险系数 内科学 冠状动脉疾病 心肌梗塞 中止 随机对照试验 心脏病学 置信区间 外科
作者
Yong‐Joon Lee,Sung‐Jin Hong,Woong Chol Kang,Bum‐Kee Hong,Jong‐Young Lee,Jin‐Bae Lee,Hyung-Jin Cho,Junghan Yoon,Seung‐Jun Lee,Chul‐Min Ahn,Jung‐Sun Kim,Byeong‐Keuk Kim,Young–Guk Ko,Donghoon Choi,Yangsoo Jang,Myeong‐Ki Hong
标识
DOI:10.1136/bmj-2023-075837
摘要

To compare the long term efficacy and safety of rosuvastatin with atorvastatin treatment in adults with coronary artery disease.Randomised, open label, multicentre trial.12 hospitals in South Korea, September 2016 to November 2019.4400 adults (age ≥19 years) with coronary artery disease.Participants were assigned to receive either rosuvastatin (n=2204) or atorvastatin (n=2196) using 2×2 factorial randomisation.The primary outcome was a three year composite of all cause death, myocardial infarction, stroke, or any coronary revascularisation. Secondary outcomes were safety endpoints: new onset diabetes mellitus; hospital admissions due to heart failure; deep vein thrombosis or pulmonary thromboembolism; endovascular revascularisation for peripheral artery disease; aortic intervention or surgery; end stage kidney disease; discontinuation of study drugs owing to intolerance; cataract surgery; and a composite of laboratory detected abnormalities.4341 of the 4400 participants (98.7%) completed the trial. Mean daily dose of study drugs was 17.1 mg (standard deviation (SD) 5.2 mg) in the rosuvastatin group and 36.0 (12.8) mg in the atorvastatin group at three years (P<0.001). The primary outcome occurred in 189 participants (8.7%) in the rosuvastatin group and 178 (8.2%) in the atorvastatin group (hazard ratio 1.06, 95% confidence interval 0.86 to 1.30; P=0.58). The mean low density lipoprotein (LDL) cholesterol level during treatment was 1.8 mmol/L (SD 0.5 mmol/L) in the rosuvastatin group and 1.9 (0.5) mmol/L in the atorvastatin group (P<0.001). The rosuvastatin group had a higher incidence of new onset diabetes mellitus requiring initiation of antidiabetics (7.2% v 5.3%; hazard ratio 1.39, 95% confidence interval 1.03 to 1.87; P=0.03) and cataract surgery (2.5% v 1.5%; 1.66, 1.07 to 2.58; P=0.02). Other safety endpoints did not differ between the two groups.In adults with coronary artery disease, rosuvastatin and atorvastatin showed comparable efficacy for the composite outcome of all cause death, myocardial infarction, stroke, or any coronary revascularisation at three years. Rosuvastatin was associated with lower LDL cholesterol levels but a higher risk of new onset diabetes mellitus requiring antidiabetics and cataract surgery compared with atorvastatin.ClinicalTrials.gov NCT02579499.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
pursuit完成签到,获得积分10
1秒前
Neltharion完成签到,获得积分10
2秒前
沈海完成签到,获得积分10
4秒前
悦耳傥完成签到 ,获得积分10
4秒前
一叶知秋应助大橙子采纳,获得10
4秒前
科研小能手完成签到,获得积分10
5秒前
guoxingliu发布了新的文献求助200
6秒前
Double_N完成签到,获得积分10
9秒前
路路完成签到 ,获得积分10
10秒前
碧蓝的盼夏完成签到,获得积分10
14秒前
AU完成签到 ,获得积分10
15秒前
研友_yLpYkn完成签到,获得积分10
16秒前
兴奋的定帮完成签到 ,获得积分0
17秒前
一叶知秋应助大橙子采纳,获得10
18秒前
19秒前
金蛋蛋完成签到 ,获得积分10
19秒前
马琛尧完成签到 ,获得积分10
21秒前
一行白鹭上青天完成签到 ,获得积分10
25秒前
帅气的宽完成签到 ,获得积分10
26秒前
lixoii完成签到 ,获得积分10
28秒前
萌萌许完成签到,获得积分10
28秒前
sunce1990完成签到 ,获得积分10
31秒前
Bin_Liu完成签到,获得积分20
32秒前
宇老师完成签到,获得积分10
32秒前
研友_VZG7GZ应助马琛尧采纳,获得10
33秒前
安安的小板栗完成签到,获得积分10
36秒前
123_完成签到,获得积分10
38秒前
NexusExplorer应助大橙子采纳,获得10
39秒前
上善若水完成签到 ,获得积分10
41秒前
qiqi发布了新的文献求助10
45秒前
45秒前
英俊的铭应助cm采纳,获得10
46秒前
47秒前
量子星尘发布了新的文献求助10
47秒前
affy210310完成签到,获得积分10
48秒前
名字不好起完成签到,获得积分10
48秒前
齐朕完成签到,获得积分10
49秒前
大橙子发布了新的文献求助10
51秒前
speed完成签到 ,获得积分10
52秒前
RYK完成签到 ,获得积分10
53秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022