机械反应
机械敏感通道
交配
愉快
嗅觉
心理学
性器官
生物
神经科学
沟通
解剖
离子通道
动物
遗传学
受体
作者
Ruby M. Lam,Lars J. von Buchholtz,Mélanie Falgairolle,Jennifer Osborne,Eleni Frangos,M. Rocio Servin‐Vences,Maximilian Nagel,Minh Quang Nguyen,Monessha Jayabalan,Dimah Saade,Ardem Patapoutian,Carsten G. Bönnemann,Nicholas J. P. Ryba,Alexander T. Chesler
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-08-25
卷期号:381 (6660): 906-910
被引量:12
标识
DOI:10.1126/science.adg0144
摘要
Despite the potential importance of genital mechanosensation for sexual reproduction, little is known about how perineal touch influences mating. We explored how mechanosensation affords exquisite awareness of the genitals and controls reproduction in mice and humans. Using genetic strategies and in vivo functional imaging, we demonstrated that the mechanosensitive ion channel PIEZO2 (piezo-type mechanosensitive ion channel component 2) is necessary for behavioral sensitivity to perineal touch. PIEZO2 function is needed for triggering a touch-evoked erection reflex and successful mating in both male and female mice. Humans with complete loss of PIEZO2 function have genital hyposensitivity and experience no direct pleasure from gentle touch or vibration. Together, our results help explain how perineal mechanoreceptors detect the gentlest of stimuli and trigger physiologically important sexual responses, thus providing a platform for exploring the sensory basis of sexual pleasure and its relationship to affective touch.
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