[Research progress of acupuncture-moxibustion in treatment of spinal cord injury through mediating inflammatory reaction].

Inflammatory reaction after spinal cord injury (SCI) is the main obstacle to the recovery of neural function. In the occurrence and development of SCI, the complex regulatory mechanisms are involved in inflammatory reaction, including the activation of inflammatory cells (e.g.macrophages and microglia), and the release of cytokines (e.g. tumor necrosis factor, interleukin and chemokines). Acupuncture-moxibustion is significantly effective in clinical treatment of SCI, and its mechanism is related to adjusting the function of inflammatory cells after SCI, modulating the expression of cytokines and the activation of NLRP3 inflammatory bodies, as well as the expression of high mobility group protein B1 and calcitonin gene related peptide. This article summarizes the research progress of mechanism of inflammatory reaction after SCI and the effects of acupuncture-moxibustion intervention in recent years so that the new ideas can be provided to clarify the pathogenesis of SCI and the effect of acupuncture-moxibustion intervention.脊髓损伤(SCI)后炎性反应是神经功能恢复的主要障碍。在SCI的发生发展中，炎性反应涉及多种复杂调节机制，包括巨噬细胞、小胶质细胞等炎性反应细胞激活，肿瘤坏死因子、白细胞介素、趋化因子等细胞因子的释放等。针灸治疗SCI临床疗效显著，其作用机制与调节SCI后炎性反应细胞功能、细胞因子表达、NOD样受体热蛋白结构域相关蛋白3炎性小体的活化、高迁移率族蛋白B1和降钙素基因相关肽的表达有关。本文总结近年来SCI炎性反应的机制研究进展及针灸干预的作用机制，为阐明SCI发病机制及针灸干预作用提供参考。.