MiR-421 mediates PM 2.5 -induced endothelial dysfunction via crosstalk between bronchial epithelial and endothelial cells

Objective PM2.5 is closely linked to vascular endothelial injury and has emerged as a major threat to human health. Our previous research indicated that exposure to PM2.5 induced an increased release of miR-421 from the bronchial epithelium. However, the role of miR-421 in PM2.5-induced endothelial injury remains elusive.