Highly efficient synthesis of enantioenriched β-hydroxy α-amino acid derivatives via Ir-catalyzed dynamic kinetic asymmetric hydrogenation

Asymmetric hydrogenation of aryl α-dibenzylamino β-ketoesters proceeded smoothly to provide the corresponding chiral aryl β-hydroxy α-amino derivatives with excellent diastereo- and enantioselectivities (>99/1 dr, up to >99% ee).