亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Dysregulation of immune and metabolism pathways in maternal immune activation induces an increased risk of autism spectrum disorders

后代 免疫系统 生物 表观遗传学 自闭症 自闭症谱系障碍 胚胎干细胞 免疫失调 基因 生物信息学 遗传学 怀孕 医学 精神科
作者
Huamin Yin,Zhendong Wang,Jiaxin Liu,Ying Li,Li Liu,Peijun Huang,Wenhang Wang,Zhiyan Shan,Ruizhen Sun,Jingling Shen,Lian Duan
出处
期刊:Life Sciences [Elsevier]
卷期号:324: 121734-121734 被引量:10
标识
DOI:10.1016/j.lfs.2023.121734
摘要

Maternal immune activation (MIA) via infection during pregnancy is known to be an environmental risk factor for neurodevelopmental disorders and the development of autism spectrum disorders (ASD) in the offspring, but it still remains elusive that the molecular relevance between infection-induced abnormal neurodevelopmental events and an increased risk for ASD development. Fully considering the extremely high genetic heterogeneity of ASD and the universality of risk-gene with minimal effect-sizes, the gene and pathway-based association analysis was performed with the transcriptomic and DNA methylation landscapes of temporal human embryonic brain development and ASD, and the time-course transcriptional profiling of MIA. We conducted the transcriptional profiling of mouse abnormal neurodevelopment two days following induced MIA via LPS injection at E10.5. A novel evidence was proved that illustrated altering four immune and metabolism-related risk pathways, including starch and sucrose metabolism, ribosome, protein processing in endoplasmic reticulum, and retrograde endocannabinoid signaling pathway, which were prominent involvement in the process of MIA regulating abnormal fetal brain development to induce an increased risk of ASD. Here, we have observed that almost all key genes within these risk pathways are significantly differentially expressed at embryonic days (E) 10.5–12.5, which is considered to be the optimal coincidence window of mouse embryonic brain development to study the intimate association between MIA and ASD using mouse animal models. There search establishes that MIA causes dysregulation of immune and metabolic pathways, which leads to abnormal embryonic neurodevelopment, thus promoting development of ASD symptoms in offspring.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
糊涂的雪旋完成签到 ,获得积分10
2秒前
kunpenezy发布了新的文献求助10
4秒前
nns发布了新的文献求助10
6秒前
蓬蒿人完成签到,获得积分10
7秒前
8秒前
SciGPT应助nns采纳,获得10
11秒前
12秒前
GG发布了新的文献求助10
12秒前
追三完成签到 ,获得积分10
12秒前
Orange应助布鲁爱思采纳,获得10
13秒前
黑大侠完成签到 ,获得积分10
15秒前
15秒前
蒲烯琳月发布了新的文献求助10
17秒前
nns完成签到,获得积分10
19秒前
22秒前
优雅草丛发布了新的文献求助30
22秒前
23秒前
Lucas应助医路通行采纳,获得10
24秒前
布鲁爱思发布了新的文献求助10
27秒前
心灵美大侠完成签到,获得积分10
27秒前
Jasmine发布了新的文献求助10
28秒前
鲍文启完成签到 ,获得积分10
38秒前
科研通AI2S应助朴素芹菜采纳,获得10
38秒前
VDC应助科研通管家采纳,获得10
51秒前
酷波er应助科研通管家采纳,获得30
51秒前
51秒前
53秒前
55秒前
朴素芹菜发布了新的文献求助10
59秒前
蒲烯琳月完成签到,获得积分20
1分钟前
大学生完成签到 ,获得积分10
1分钟前
1分钟前
Bighen完成签到 ,获得积分10
1分钟前
中陆完成签到,获得积分10
1分钟前
1分钟前
优雅草丛完成签到,获得积分10
1分钟前
白桦发布了新的文献求助10
1分钟前
文武完成签到 ,获得积分10
1分钟前
冕镜完成签到 ,获得积分10
1分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3200652
求助须知:如何正确求助?哪些是违规求助? 2850426
关于积分的说明 8072014
捐赠科研通 2514173
什么是DOI,文献DOI怎么找? 1346912
科研通“疑难数据库(出版商)”最低求助积分说明 640281
邀请新用户注册赠送积分活动 610407