Additive effect of hypertension on left ventricular structure and function in patients with asymptomatic type 2 diabetes mellitus

医学 心脏病学 内科学 糖尿病 无症状的 背景(考古学) 2型糖尿病 微循环 心脏磁共振成像 心室重构 舒张期 心力衰竭 糖尿病性心肌病 灌注 血压 磁共振成像 内分泌学 心肌病 放射科 古生物学 生物
作者
Li Jiang,Yan Ren,Hong Yu,Yingkun Guo,Xi Liu,Mingyan Deng,Linjun Xie,Yukui Zhang,Mengting Shen,Pei‐Lun Han,Zhi‐gang Yang
出处
期刊:Journal of Hypertension [Ovid Technologies (Wolters Kluwer)]
卷期号:39 (3): 538-547 被引量:8
标识
DOI:10.1097/hjh.0000000000002643
摘要

We aimed to comprehensively determine the effects of hypertension on left ventricular (LV) structure, microcirculation, tissue characteristics, and deformation in type 2 diabetes mellitus (T2DM) using multiparametric cardiac magnetic resonance (CMR) imaging.We prospectively enrolled 138 asymptomatic patients with T2DM (80 normotensive and 58 hypertensive individuals) and 42 normal glucose-tolerant and normotensive controls and performed multiparametric CMR examination to assess cardiac geometry, microvascular perfusion, extracellular volume (ECV), and strain. Univariable and multivariable linear analysis was performed to analyze the effect of hypertension on LV deformation in patients with T2DM.Compared with controls, patients with T2DM exhibited decreased strain, decreased microvascular perfusion, increased LV remodeling index, and increased ECV. Hypertension lead to greater deterioration of LV strain (peak strain-radial, P = 0.002; peak strain-longitudinal, P = 0.006) and LV remodeling index (P = 0.005) in patients with T2DM after adjustment for covariates; however, it did not affect microvascular perfusion (perfusion index, P = 0.469) and ECV (P = 0.375). In multivariable analysis, hypertension and diabetes were independent predictors of reduced LV strain, whereas hypertension is associated with greater impairment of diastolic function (P = 0.009) but not systolic function (P = 0.125) in the context of diabetes, independent of clinical factors and myocardial disorder.Hypertension in the context of diabetes is significantly associated with LV diastolic function and concentric remodeling; however, it has little effect on systolic function, myocardial microcirculation, or fibrosis independent of covariates, which provide clinical evidence for understanding the pathogenesis of comorbidities and explaining the development of distinct heart failure phenotypes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
高兴帅哥完成签到,获得积分10
1秒前
3秒前
aslink完成签到,获得积分10
3秒前
Amon完成签到,获得积分10
3秒前
啊娴仔发布了新的文献求助10
3秒前
camellia发布了新的文献求助10
3秒前
万能图书馆应助狂野觅云采纳,获得10
3秒前
充电宝应助zino采纳,获得10
4秒前
4秒前
小可发布了新的文献求助10
4秒前
英姑应助酷酷的起眸采纳,获得10
5秒前
Blue_Pig发布了新的文献求助10
5秒前
科研小白完成签到,获得积分10
6秒前
sooya发布了新的文献求助20
7秒前
7秒前
tiddler完成签到,获得积分10
7秒前
科研通AI2S应助滴滴采纳,获得10
7秒前
wgx完成签到,获得积分20
7秒前
8秒前
爱静静应助Keep采纳,获得10
8秒前
8秒前
8秒前
小马甲应助韭菜采纳,获得10
9秒前
MADKAI发布了新的文献求助10
9秒前
机智的白猫完成签到,获得积分10
9秒前
李健的小迷弟应助xxx采纳,获得10
9秒前
杜杜完成签到,获得积分10
9秒前
NexusExplorer应助新的心跳采纳,获得10
10秒前
11秒前
11秒前
11秒前
11秒前
11秒前
JamesPei应助小可采纳,获得10
11秒前
粗暴的醉卉完成签到,获得积分10
11秒前
11秒前
科研通AI5应助stt采纳,获得10
12秒前
sunzhiyu233发布了新的文献求助10
13秒前
13秒前
缓缓地安静关注了科研通微信公众号
14秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Social media impact on athlete mental health: #RealityCheck 1020
Ensartinib (Ensacove) for Non-Small Cell Lung Cancer 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
Bacterial collagenases and their clinical applications 800
El viaje de una vida: Memorias de María Lecea 800
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3527699
求助须知:如何正确求助?哪些是违规求助? 3107752
关于积分的说明 9286499
捐赠科研通 2805513
什么是DOI,文献DOI怎么找? 1539954
邀请新用户注册赠送积分活动 716878
科研通“疑难数据库(出版商)”最低求助积分说明 709759