<p>A New Type of MgFe<sub>2</sub>O<sub>4</sub>@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release</p>

Introduction:Cancer is a major health problem worldwide, and the most extensive treatment can be obtained by using chemotherapy in the clinic.However, due to the low selectivity of cancer cells, chemotherapy drugs produce a series of grievous side effects on normal cells.Methods: In this research, we developed novel nanocarriers for magnetically targeted nearinfrared (NIR) light-electromagnetic wave dual controlled drug delivery based on MgFe 2 O 4 @CuS nanoparticles (NPs) modified with aminopropyltriethoxysilane (APTES) in response to magnetic, NIR light, and electromagnetic wave irradiation.Synthesis and characterization of MgFe 2 O 4 @CuS-APTES NPs was carried out using X-ray diffraction measurements, scanning electron microscopy, transmission electron microscopy, photoluminescence emission spectra, UV-1800 spectrophotometer, N5230A vector network analyzer, MDS-6 microwave sample preparation system, and superconducting quantum interference device.In addition to that mentioned above, we also explored many other sides, such as the drug-loading, drug-controlled release efficiency, elect99omagnetic wave thermal effect and photo-thermal effect. Results:The results showed that APTES-modified MgFe 2 O 4 @CuS NPs had 37% high drugloading capacity and high electromagnetic wave thermal conversion ability and NIR-light thermal conversion ability.In addition, ibuprofen (IBU) release from the MgFe 2 O 4 @CuS-APTES-IBU depends on the electromagnetic wave (2.45 GHz) and 1060 nm NIR light irradiation.After five cycles, the drug-release percentage was 90% and 66% separately, and could be adjusted by the time and cycles times of electromagnetic wave and NIR light irritation.Electromagnetic wave irradiation compared with NIR light irradiation, has a higher drug release rate and better penetration.Therefore, choosing different stimulation methods according to the treatment needs of the disease, we can achieve accurate personalized treatment of the disease.Discussion: Our findings indicate that multifunctional APTES modified MgFe 2 O 4 @CuS NPs could be used for the first time as a new drug carrier for "location-timing-quantification" drug release with magnetic targeting and dual control of NIR light-electromagnetic waves.