整体
催化作用
化学
微型反应器
聚苯乙烯
流动化学
连续流动
化学工程
钯
催化剂载体
表面改性
填充床
纳米技术
组合化学
有机化学
色谱法
材料科学
聚合物
工程类
物理化学
物理
机械
作者
M. Grace Russell,Cedrick Veryser,J. F. Hunter,Rachel L. Beingessner,Timothy F. Jamison
标识
DOI:10.1002/adsc.201901185
摘要
Abstract Monolithic and packed‐bed reactors featuring immobilized catalysts are well‐precedented in continuous flow synthesis but can suffer from adverse pressure drops during use due to their small pore sizes and/or structural changes. Herein, we overcome this challenge with the synthesis of a structurally robust silica‐based monolith featuring pore sizes on the millimeter scale. The 3‐dimensional solid support structure is constructed from a polystyrene foam‐based template and features a functional group handle that can be modified to display a reactive catalyst. Here we functionalize the support with palladium(0) for hydrogenation reactions and a modified proline catalyst for the alpha functionalization of aldehydes. Both reactors showed good activity and excellent catalytic longevity when utilized under continuous flow conditions. magnified image
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