Intestinal Absorption of Bile Acids in Health and Disease

Intestinal Absorption of Bile Acids in Health and Disease Volume 10 Issue 1. January 2020 Alexander L. Ticho, Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USASearch for more papers by this authorPooja Malhotra, Division of Gastroenterology & Hepatology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USASearch for more papers by this authorPradeep K. Dudeja, Division of Gastroenterology & Hepatology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Jesse Brown VA Medical Center, Chicago, Illinois, USASearch for more papers by this authorRavinder K. Gill, Division of Gastroenterology & Hepatology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USASearch for more papers by this authorWaddah A. Alrefai, Corresponding Author Division of Gastroenterology & Hepatology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Jesse Brown VA Medical Center, Chicago, Illinois, USACorrespondence to walrefai@uic.eduSearch for more papers by this author Alexander L. Ticho, Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USASearch for more papers by this authorPooja Malhotra, Division of Gastroenterology & Hepatology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USASearch for more papers by this authorPradeep K. Dudeja, Division of Gastroenterology & Hepatology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Jesse Brown VA Medical Center, Chicago, Illinois, USASearch for more papers by this authorRavinder K. Gill, Division of Gastroenterology & Hepatology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USASearch for more papers by this authorWaddah A. Alrefai, Corresponding Author Division of Gastroenterology & Hepatology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Jesse Brown VA Medical Center, Chicago, Illinois, USACorrespondence to walrefai@uic.eduSearch for more papers by this author https://doi.org/10.1002/cphy.c190007Citations: 17 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic circulation. The majority of bile acids are actively absorbed via specific transport proteins that are highly expressed in the distal ileum. The uptake of bile acids by intestinal epithelial cells modulates the activation of cytosolic and membrane receptors such as the farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (GPBAR1), which has a profound effect on hepatic synthesis of bile acids as well as glucose and lipid metabolism. Extensive research has focused on delineating the processes of bile acid absorption and determining the contribution of dysregulated ileal signaling in the development of intestinal and hepatic disorders. For example, a decrease in the levels of the bile acid-induced ileal hormone FGF15/19 is implicated in bile acid-induced diarrhea (BAD). Conversely, the increase in bile acid absorption with subsequent overload of bile acids could be involved in the pathophysiology of liver and metabolic disorders such as fatty liver diseases and type 2 diabetes mellitus. This review article will attempt to provide a comprehensive overview of the mechanisms involved in the intestinal handling of bile acids, the pathological implications of disrupted intestinal bile acid homeostasis, and the potential therapeutic targets for the treatment of bile acid-related disorders. Published 2020. Compr Physiol 10:21-56, 2020. Citing Literature Comprehensive PhysiologyBrowse other articles of this reference work:BROWSE TABLE OF CONTENTSBROWSE BY TOPICBROWSE A-Z RelatedInformation