周细胞
内分泌学
内科学
生物
医学
糖尿病
内皮干细胞
生物化学
体外
作者
Yedan Liu,Huawei Zhang,Shaoxun Wang,Ya Guo,Xing Fang,Baoying Zheng,Wen‐Jun Gao,Hongwei Yu,Zongbo Chen,Richard J. Roman,Fan Fan
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physical Society]
日期:2020-12-11
卷期号:320 (2): H549-H562
被引量:54
标识
DOI:10.1152/ajpheart.00726.2020
摘要
This study demonstrates that the loss of contractile capability in pericytes in diabetes is associated with enhanced ROS and reduced ATP production. Enhanced advanced glycation end products (AGEs) in diabetes accompany with reduced pericyte and endothelial tight junction coverage in the cortical capillaries of old diabetic rats. These results suggest our previous findings that the impaired cerebral hemodynamics, BBB leakage, and cognitive impairments in old DM model are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction.
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