As an important base for cultivating special education talents, the effectiveness of the safety management work of special education professional laboratories directly affects the life safety of teachers and students and the teaching order. This thesis analyzes the current situation of safety management of special education professional laboratories in general teacher training colleges, discusses the existing problems and their causes, and puts forward corresponding improvement strategies. The results of the study show that improving the management system, strengthening safety training, updating experimental equipment and perfecting the emergency plan are the keys to improve the safety management level of special education professional laboratories.