Biomimicking Covalent Organic Frameworks Nanocomposite Coating for Integrated Enhanced Anticorrosion and Antifouling Properties of a Biodegradable Magnesium Stent

生物污染 材料科学 涂层 生物相容性 纳米复合材料 纳米技术 腐蚀 结垢 支架 多孔性 复合材料 冶金 化学 外科 医学 生物化学
作者
Rui Zan,Hao Wang,Sheng Shen,Shi Yang,Han Yu,Xiyue Zhang,Xian Zhang,Xiang Chen,Mengxuan Shu,Xiao Yang Lu,Jiazeng Xia,Yaqi Gu,Houbao Liu,Yongping Zhou,Xiaonong Zhang,Tao Suo
出处
期刊:Acta Biomaterialia [Elsevier BV]
标识
DOI:10.1016/j.actbio.2024.04.012
摘要

The utilization of biodegradable magnesium (Mg) alloys in the fabrication of temporary non-vascular stents is an innovative trend in biomedical engineering. However, the heterogeneous degradation profiles of these biomaterials, together with potential bacterial colonization that could precipitate infectious or stenotic complications, are critical obstacles precluding their widespread clinical application. In pursuit of overcoming these limitations, this study applies the principles of biomimicry, particularly the hydrophobic and anti-fouling characteristics of lotus leaves, to pioneer the creation of nanocomposite coatings. These coatings integrate poly-trimethylene carbonate (PTMC) with covalent organic frameworks (COFs), constituting a multiscale crosslinked network that modifies the stent's surface microstructure. The strategic design of the coating's topography, porosity, and self-polishing capabilities collectively aims to decelerate degradation processes and minimize biological adhesion. The protective qualities of the coatings were substantiated through rigorous testing in both in vitro dynamic bile tests and in vivo New Zealand rabbit choledochal models. Empirical findings from these trials confirmed that the implementation of COF-based nanocomposite coatings robustly fortifies Mg implantations, conferring heightened resistance to both biocorrosion and biofouling as well as improved biocompatibility within bodily environments. The outcomes of this research elucidate a comprehensive framework for the multifaceted strategies against stent corrosion and fouling, thereby charting a visionary pathway toward the systematic conception of a new class of reliable COF-derived surface modifications poised to amplify the efficacy of Mg-based stents. Biodegradable magnesium (Mg) alloys are widely utilized in temporary stents, though their rapid degradation and susceptibility to bacterial infection pose significant challenges. Our research has developed a nanocomposite coating inspired by the lotus, integrating poly-trimethylene carbonate with covalent organic frameworks (COF). The coating achieved self-polishing property and optimal surface energy on the Mg substrate, which decelerates stent degradation and reduces biofilm formation. Comprehensive evaluations utilizing dynamic bile simulations and implantation in New Zealand rabbit choledochal models reveal that the coating improves the durability and longevity of the stent. The implications of these findings suggest the potential COF-based Mg alloy stent surface treatments and a leap forward in advancing stent performance and endurance in clinical applications.
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