Nickel‐Catalyzed Cyanation of Vinyl Triflates with Isonitrile as a Nucleophilic CN Source

We report a nickel‐catalyzed cyanation of vinyl triflates using tert‐butyl isonitrile as a nucleophilic CN source. This reaction employs simple Ni(OTf)₂ as the catalyst, operating without exogenous ligands or reductants. The method enables selective and efficient access to a broad range of cyclic and acyclic alkenyl nitriles, accommodating diverse functional groups and substrates, including natural products and pharmaceuticals.