From suppressor to enhancer: IL-10’s alternative role in CAR-T cell therapies against solid tumors

Aiming to improve the effector function of CAR-T cells, Zhao et al. 1 Zhao Y. Chen J. Andreatta M. Feng B. Xie Y.Q. Wenes M. Wang Y. Gao M. Hu X. Romero P. et al. IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases. Nat. Biotechnol. 2024; : 1-12 PubMed Google Scholar report that IL-10 metabolically reprograms CAR-T cells, and this promotes their effectiveness against solid tumors and challenges IL-10's perceived role as merely immunosuppressive. This simple but promising strategy fosters durable immune memory and eagerly awaits validation in clinical trials. Aiming to improve the effector function of CAR-T cells, Zhao et al. 1 Zhao Y. Chen J. Andreatta M. Feng B. Xie Y.Q. Wenes M. Wang Y. Gao M. Hu X. Romero P. et al. IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases. Nat. Biotechnol. 2024; : 1-12 PubMed Google Scholar report that IL-10 metabolically reprograms CAR-T cells, and this promotes their effectiveness against solid tumors and challenges IL-10's perceived role as merely immunosuppressive. This simple but promising strategy fosters durable immune memory and eagerly awaits validation in clinical trials.