透皮
生物电子学
角质层
纳米技术
数码产品
可穿戴计算机
计算机科学
材料科学
生物医学工程
医学
工程类
嵌入式系统
电气工程
生物传感器
药理学
病理
作者
Zifeng Wang,Min Xiao,Zhanhong Li,Xinghao Wang,Fangjie Li,Huayuan Yang,Yu Chen,Zhigang Zhu
标识
DOI:10.1002/adhm.202303921
摘要
Abstract Wearable epidermal electronics with non‐ or minimally‐invasive characteristics can collect, transduce, communicate, and interact with accessible physicochemical health indicators on the skin. However, due to the stratum corneum layer, rich information about body health is buried under the skin stratum corneum layer, for example, in the skin interstitial fluid. Microneedle patches are typically designed with arrays of special microsized needles of length within 1000 µm. Such characteristics potentially enable the access and sample of biomolecules under the skin or give therapeutical treatment painlessly and transdermally. Integrating microneedle patches with various electronics allows highly efficient transdermal bioelectronics, showing their great promise for biomedical and healthcare applications. This comprehensive review summarizes and highlights the recent progress on integrated transdermal bioelectronics based on microneedle patches. The design criteria and state‐of‐the‐art fabrication techniques for such devices are initially discussed. Next, devices with different functions, including but not limited to health monitoring, drug delivery, and therapeutical treatment, are highlighted in detail. Finally, key issues associated with current technologies and future opportunities are elaborated to sort out the state of recent research, point out potential bottlenecks, and provide future research directions.
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