Blood manganese level and gestational diabetes mellitus: a systematic review and meta-analysis

医学 妊娠期糖尿病 荟萃分析 子群分析 优势比 置信区间 科克伦图书馆 观察研究 糖尿病 梅德林 内科学 产科 怀孕 妊娠期 内分泌学 遗传学 生物 政治学 法学
作者
Yingmei Sun,Yu Zhang
出处
期刊:Journal of Obstetrics and Gynaecology [Informa]
卷期号:43 (2) 被引量:1
标识
DOI:10.1080/01443615.2023.2266646
摘要

Previous studies evaluating the relationship between blood manganese (Mn) level and gestational diabetes mellitus (GDM) in pregnant women showed inconsistent results. A systematic review and meta-analysis was therefore performed to investigate the above association.Relevant observational studies were obtained by search of electronic databases including Medline, Embase, Cochrane Library and Web of Science from database inception to 10 March 2023. Two authors independently performed database search, literature identification and data extraction. A randomised-effects model was selected to pool the data by incorporating the influence of potential heterogeneity. Subgroup analysis was performed to evaluate the influence of study characteristics on the results of the meta-analysis.Six datasets from five observational studies, involving 91,249 pregnant women were included in the meta-analysis. Among the participants, 3597 (3.9%) were diagnosed as GDM. Overall, pooled results showed that a high blood level of Mn was associated with a higher risk of GDM (compared between women with highest versus lowest category blood Mn, odds ratio: 1.31, 95% confidence interval: 1.19-1.44, p < .001) with no significant heterogeneity (p for Cochrane Q-test = 0.93, I2 = 0%). Subgroup analyses according to study design, mean maternal age, matrix or methods for measuring blood Mn, and the incidence of GDM also showed consistent results (p for subgroup difference all >.05).Results of the meta-analysis suggest that a high blood Mn level may be a risk factor of GDM in pregnant women. Studies are needed to determine the underlying mechanisms, and to investigate if the relationship between blood Mn level and GDM is dose-dependent.Changes of blood manganese (Mn) have been suggested to be involved in the pathogenesis of diabetes. However, the relationship between blood Mn level and gestational diabetes mellitus (GDM) in pregnant women remains undetermined. Our study represents the first systematic review and meta-analysis to investigate the potential association between blood Mn concentration and the risk of GDM. In this meta-analysis, we pooled the results of six datasets from five observational and showed that compared to pregnant women with the lowest category of blood Mn level, those with the highest category of blood Mn level were associated with a higher risk of GDM. These results suggest that a high blood concentration of Mn in pregnant women may be a risk factor of GDM.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
抹茶肥肠完成签到,获得积分10
3秒前
脑洞疼应助11采纳,获得10
3秒前
3秒前
5秒前
sheila完成签到,获得积分10
5秒前
5秒前
枫叶的虫子完成签到,获得积分10
6秒前
6秒前
Pooh发布了新的文献求助10
7秒前
7秒前
8秒前
深情安青应助莫非采纳,获得10
9秒前
向阳而生o完成签到,获得积分10
9秒前
xxx发布了新的文献求助10
9秒前
10秒前
llll发布了新的文献求助10
11秒前
yao发布了新的文献求助30
11秒前
12秒前
loski发布了新的文献求助10
12秒前
可爱的函函应助偷乐采纳,获得10
14秒前
清晾油完成签到,获得积分10
14秒前
15秒前
脑洞疼应助科研通管家采纳,获得10
15秒前
科目三应助科研通管家采纳,获得10
15秒前
坦率的匪应助科研通管家采纳,获得10
15秒前
科研通AI5应助科研通管家采纳,获得10
15秒前
JamesPei应助科研通管家采纳,获得10
15秒前
解语花应助科研通管家采纳,获得50
15秒前
czh应助科研通管家采纳,获得10
15秒前
JamesPei应助科研通管家采纳,获得10
15秒前
科研通AI2S应助科研通管家采纳,获得10
15秒前
bkagyin应助科研通管家采纳,获得10
15秒前
Hello应助科研通管家采纳,获得10
15秒前
坦率的匪应助科研通管家采纳,获得10
15秒前
ludov应助科研通管家采纳,获得10
15秒前
16秒前
搜集达人应助科研通管家采纳,获得10
16秒前
隐形曼青应助科研通管家采纳,获得10
16秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988838
求助须知:如何正确求助?哪些是违规求助? 3531250
关于积分的说明 11252914
捐赠科研通 3269838
什么是DOI,文献DOI怎么找? 1804820
邀请新用户注册赠送积分活动 881943
科研通“疑难数据库(出版商)”最低求助积分说明 809028