Bovine Milk Proteome: Milk Fat Globule Membrane Protein Is the Most Sensitive Fraction in Response to High Somatic Cell Count

微泡 脂肪球 外体 蛋白质组 化学 体细胞 膜蛋白 脂质代谢 食品科学 生物化学 生物 乳脂 小RNA 基因 亚麻籽油
作者
Bin Yang,Fang He,Huan Cheng,Robert W. Hu,Jianbo Li,Kangle Yi,Zhiwei Kong,Yang Luo
出处
期刊:Journal of Agricultural and Food Chemistry [American Chemical Society]
卷期号:71 (42): 15884-15893
标识
DOI:10.1021/acs.jafc.3c04480
摘要

The impacts of high milk somatic cell count (SCC) on different milk fractions are not well understood. In this study, proteins in milk exosomes, milk fat globule membrane (MFGM), and whey from cows with low (<105 cells/mL, CG) and high SCC (>5 × 105 cells/mL, HSG) were identified using a tandem mass tag proteomic approach. In total, 1568, 2160, and 1002 proteins were identified, with 65, 552, and 98 proteins being altered by high SCC in exosomes, MFGM, and whey, respectively. With high SCC, the exosome marker (ACTB) was increased in the exosomes of HSG. The main MFGM proteins (BTN1A1, PLIN3, FABP3, and MFGE8) and functional proteins (MUC1, IGSF5, TLR5, and CD36/14) were decreased, while the lipid/energy metabolism-related proteins were increased in the MFGM of HSG. The glycolysis-related proteins were increased in the whey of HSG. Also, the host defense/inflammation-related proteins were changed in three fractions under high SCCs. MFGM was the most sensitive fraction to a high SCC, followed by whey. These findings provide guidance for the early detection of unhealthy mammary glands.
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