心脏毒性
类有机物
医学
药品
阿霉素
药理学
药物开发
心功能曲线
生物信息学
心脏病学
毒性
神经科学
内科学
心力衰竭
生物
化疗
作者
Xi Chen,Na Lu,Shengbo Huang,Qian Zhang,Zongjun Liu,Xin Wang
标识
DOI:10.1016/j.cbi.2023.110777
摘要
Cardiovascular diseases pose a huge threat to global human health and are also a major obstacle to drug development and disease treatment. Drug-induced cardiotoxicity remains an important clinical issue. Both traditional two-dimensional (2D) monolayer cell models and animal models have their own limitations and are not fully suitable for the study of human heart physiology or pathology. Cardiac organoids are three-dimensional (3D) and self-organized structures that accurately retain the biological characteristics and functions of heart tissue. In this study, we successfully established a human cardiac organoid model by inducing the directed differentiation of human embryonic stem cells, which recapitulates the patterns of early myocardial development. Moreover, this model accurately characterized the cardiotoxic damage caused by the anticancer drug doxorubicin, including clinical cardiac injury and cardiac function indicators, cell apoptosis, inflammation, fibrosis, as well as mitochondrial damage. In general, the cardiac organoid model can be used to evaluate the cardiotoxicity of drugs, opening new directions and ideas for drug screening and cardiotoxicity research.
科研通智能强力驱动
Strongly Powered by AbleSci AI