生物膜
微生物学
生物
抗真菌药
抗药性
白色念珠菌
细胞外基质
抗真菌
细菌
细胞生物学
遗传学
作者
Justin Massey,Robert Żarnowski,David R. Andes
出处
期刊:Fems Microbiology Reviews
[Oxford University Press]
日期:2023-10-10
卷期号:47 (6)
被引量:7
标识
DOI:10.1093/femsre/fuad059
摘要
Abstract Clinical infection due to Candida species frequently involve growth in biofilm communities. Recalcitrance despite antifungal therapy leads to disease persistence associated with high morbidity and mortality. Candida possesses several tools allowing evasion of antifungal effects. Among these, protection of biofilm cells via encasement by the extracellular matrix is responsible for a majority drug resistance phenotype. The Candida matrix composition is complex and includes a mannan–glucan complex linked to antifungal drug sequestration. This mechanism of resistance is conserved across the Candida genus and impacts each of the available antifungal drug classes. The exosome pathway is responsible for delivery and assembly of much of the Candida extracellular matrix as functional vesicle protein and polysaccharide cargo. Investigations demonstrate the vesicle matrix delivery pathway is a useful fungal biofilm drug target. Further elucidation of the vesicle pathway, as well as understanding the roles of biofilm driven cargo may provide additional targets to aid the diagnosis, prevention, and treatment of Candida biofilms.
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