脱甲基酶
染色质
表观遗传学
生物
组蛋白
功能(生物学)
染色质重塑
转录因子
细胞生物学
计算生物学
DNA修复
癌症研究
DNA
基因
遗传学
作者
Yuanyuan Jiang,Lanxin Liu,Zeng-Quan Yang
标识
DOI:10.1007/978-3-031-38176-8_5
摘要
KDM4 histone demethylases mainly catalyze the removal of methyl marks from H3K9 and H3K36 to epigenetically regulate chromatin structure and gene expression. KDM4 expression is strictly regulated to ensure proper function in a myriad of biological processes, including transcription, cellular proliferation and differentiation, DNA damage repair, immune response, and stem cell self-renewal. Aberrant expression of KDM4 demethylase has been documented in many types of blood and solid tumors, and thus, KDM4s represent promising therapeutic targets. In this chapter, we summarize the current knowledge of the structures and regulatory mechanisms of KDM4 proteins and our understanding of their alterations in human pathological processes with a focus on development and cancer. We also review the reported KDM4 inhibitors and discuss their potential as therapeutic agents.
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