Antimicrobial peptides, otherwise called AMPs, are a group of somewhat little peptides that are tracked down in overflow all through nature. These peptides are a fundamental part of the inborn invulnerable frameworks of different creatures. AMPs are known to hinder the development of a wide assortment of microorganisms, including microscopic organisms, growth, parasites, and infections. Antimicrobial treatment has been met with significant trouble because of the disturbing ascent in the commonness of ailments impervious to antimicrobial medications. The improvement of antimicrobial opposition is a worldwide worry that affects medical services frameworks as well as has extreme repercussions for the political and financial frameworks of the world. In this paper, we talked about antimicrobial peptides (AMPs), their design, beginning, history, and classes. In this article, we discuss the mechanism of action, usage, and immunomodulatory effects of antimicrobial peptides. Further in this paper, we investigate biofilms, persister cells, and drug-resistant bacteria as new AMP targets, antimicrobial peptide resistance, elements considered for designing synthetic AMPs, The Expansion of Antimicrobial Peptide Diversity and Guidelines for Enhancing Antimicrobial Peptides. The results of this investigation will give an expansion and refinement of our existing knowledge of AMPs. In this study, our goals are to offer a concise overview of the criteria for antimicrobial peptides (AMP), as well as extensive information regarding the antibacterial activity of these peptides.