伤口愈合
光热治疗
过氧化氢酶
化学
自愈水凝胶
光热效应
细胞迁移
氧化应激
微生物学
细胞
材料科学
免疫学
医学
纳米技术
生物化学
生物
有机化学
作者
Linjie Huang,Jing-Wen Deng,Yina Su,Xueqi Hu,Yichao Zhang,Shanni Hong,Xiahui Lin
出处
期刊:Antioxidants
[Multidisciplinary Digital Publishing Institute]
日期:2024-07-17
卷期号:13 (7): 857-857
被引量:1
标识
DOI:10.3390/antiox13070857
摘要
Skin damage is one of the most prevalent human injuries, which affects the health of human beings. However, skin damage is often accompanied by bacterial infection and wound microenvironment changes, causing damage to normal cells and inhibiting wound healing. Herein, we designed a thermal-responsive antibacterial hydrogel (GAG hydrogel) loaded with catalase (CAT)-like Au@Pt@MgSiO3 nanoparticles (APM NPs) and gentamicin (GM) to promote wound healing. The GAG hydrogel was used in a photothermal therapy (PTT)/antibiotic combination to kill bacteria, reduce the use of antibiotics, improve the wound microenvironment, promote cell proliferation, and accelerate wound healing. Under near-infrared laser irradiation, APM NPs in the hydrogel generated local hyperthermia to kill bacteria. Meanwhile, the generated heat led to a change in the hydrogel’s morphology, enabling it to release GM and APM NPs to prevent the overuse of antibiotics. Subsequently, the CAT-like ability of the APM NPs decreased the oxidative stress caused by hydrogen peroxide (H2O2), thus remodeling the wound microenvironment. Then, the weakly acidic microenvironment of the wound caused the decomposition of the APM NPs and the release of magnesium ions (Mg2+), promoting the growth and migration of cells for wound healing. Therefore, the studied thermal-responsive antibacterial (GAG) hydrogel has potential in the field of wound healing.
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