镱
发光
纳米晶
荧光
调节器
材料科学
光电子学
纳米技术
分析化学(期刊)
化学
光学
物理
兴奋剂
色谱法
生物化学
基因
作者
Wang Wang,Jinqiu Yang,Bolin Ma,Haoyu Zhu,Yaqi Zhu,Yuexi Yi,Xiaodan Li,Q. D. Li,Hao Chen,Bin Li,Xianggui Kong,Yulei Chang
标识
DOI:10.1002/lpor.202400786
摘要
Abstract Fluorescence/luminescence bioimaging, utilizing rare‐earth doped nanocrystals (RENCs) within the NIR‐IIb (1500–1700 nm) sub‐window, has drawn interest for its deep penetration depth and superior resolution. Herein, Er 3+ /Yb 3+ couple is rationally designed in topologically arranged RENCs that facilitate a boosted 1530 nm emission of Er 3+ via premeditated Yb 3+ ‐mediated energy transfer processes under 808 nm excitation. To maximize this modulation effect for boosting 1530 nm emission, a regional active ions concentration and spatial regulation strategy is explored in the optimized concentration and core–shell–shell structure (NaErF 4 :20%Yb@NaYbF 4 :20%Er@NaYF 4 with a quantum yield of 16.46% in NIR‐IIb region). Leveraging the superior emission and multi‐wavelength excitation characteristics of the as‐obtained nanocrystals, a NIR‐IIb‐based ratiometric fluorescence imaging measurement is achieved under 808 and 980 nm excitation, which cannot only show the 2D distribution of probes but also provide spatial depth information (range from 0 to 2.8 mm with a tissue depth resolution of 66 µm). The findings hold significant potential for advancing both vascular science and clinical medicine.
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