生物
益生菌
溃疡性结肠炎
平衡
肠道菌群
结肠炎
微生物学
细胞生物学
细菌
免疫学
内科学
疾病
医学
遗传学
作者
Peilin Guo,Xilong Zhang,Qian Xiang,Chao Pan,Yefeng Qiu,Tingting Li,Dongfang Wang,Jing Wang,Rongrong Jia,Minmin Shi,Yukui Zhang,Junxia Li,Jiang Zou,Yuan Zhong,Jiawei Zhao,Di‐Wei Zheng,Yimin Cui,Guanghui Ma,Wei Wei
标识
DOI:10.1016/j.chom.2024.07.028
摘要
Probiotics are potential treatments for ulcerative colitis (UC), but their efficacy is frequently compromised by gastrointestinal conditions that limit adhesion and activity. Here, we use machine learning and bioinformatics to confirm that patients with UC have decreased prevalence of Lactobacillus genus and increased oxidative stress, which correlate with inflammation severity. Accordingly, we developed a probiotic-based therapeutic that synergistically restores intestinal redox and microbiota homeostasis. Lactobacillus casei (Lac) were induced to form a pericellular film, providing a polysaccharide network for spatially confined crystallization of ultrasmall but highly active selenium dots (Se-Lac). Upon oral administration, the selenium dot-embedded pericellular film efficiently enhanced gastric acid resistance and intestinal mucoadhesion of Lac cells. At the lesion site, the selenium dots scavenged reactive oxygen species, while Lac modulated the gut microbiota. In multiple mouse models and non-human primates, this therapeutic effectively relieved inflammation and reduced colonic damage, thus showing promise as a UC treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI