休止角
造粒
颗粒(地质)
流化床
材料科学
响应面法
工艺优化
复合材料
色谱法
化学
化学工程
热力学
工程类
物理
作者
Vinod V. Kenekar,Suhas B. Ghugare,Veena Patil-Shinde
标识
DOI:10.1016/j.powtec.2023.118373
摘要
This study determines the effects of influential process parameters of high-shear wet granulation (HSWG) on the critical process and quality attributes of the granules. The wet granules from HSWG experiments were dried in a fluidized bed dryer wherein the granule drying characteristics were analyzed by introducing Page's equation, which fits well with R2 values of above 0.95 for all the batches. Response surface methodology (RSM) based nonlinear models predicting the drying time, flow angle of repose, and surface mean diameter of the granules effectively capture the granulation phenomena with high correlation coefficients of above 0.93. Multi-objective constrained grid-search (MOCGS) optimization is utilized to optimize the HSWG process. Selected optimization results include the minimum drying time of 23 min, the minimum flow angle of repose of granules as 21° and the maximum surface mean diameter of the granules as 0.62 mm for the batch size of 1.8 kg.
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