Recent advances in nickel-catalyzed asymmetric hydrofunctionalization of alkenes

催化作用 化学 有机化学
作者
Xiaoya Sun,Bo-Ying Yao,Bin Xuan,Li‐Jun Xiao,Qi‐Lin Zhou
出处
期刊:Chem catalysis [Elsevier]
卷期号:2 (11): 3140-3162 被引量:34
标识
DOI:10.1016/j.checat.2022.10.020
摘要

Nickel-catalyzed reactions have attracted more and more attention. A variety of transformations of organic compounds have been achieved through single-electron or two-electron transfer processes catalyzed by nickel. In these transformations, asymmetric hydrofunctionalization of alkenes, in which a hydrogen atom and a functional group are enantioselectively added across to C–C double bonds of alkenes, allows the construction of value-added optically active molecules from readily available raw materials. These reactions fulfill the growing demands for highly efficient, atom-economical, and green synthesis. This review overviews recent developments in the nickel-catalyzed intermolecular asymmetric hydrofunctionalization of alkenes under reductive and redox-neutral conditions. Nickel-catalyzed asymmetric hydrofunctionalization reactions of alkenes provide an atom- and step-economical method for synthesizing optically active molecules and attracts increasing attention in recent years. These reactions are initiated by Ni-H species, so finding an eligible hydrogen source to form Ni-H species is crucial for the success of the reactions. Efficient chiral ligands are another key to control enantioselectivity. This review summarizes recent advances in the nickel-catalyzed intermolecular asymmetric hydrofunctionalization of alkenes via an Ni-H intermediate under reductive or redox-neutral conditions. Perhaps, the most ideal nickel-catalyzed asymmetric hydrofunctionalization of alkenes go through the direct addition of H-X (X = C, N, P, O, S, etc.) with nickel to form Ni-H species without the use of stochiometric reductants. Thus, we hope that this review will encourage future research toward redox-neutral nickel-catalyzed asymmetric hydrofunctionalization of alkenes. Due to the growing demands for environmentally friendly and sustainable processes in recent organic synthesis, it becomes important to use earth-abundant metals as catalysts to transfer available raw materials to valuable products via efficient and atom-economical reactions. Nickel-catalyzed hydrofunctionalization reactions of alkenes undoubtedly fulfill the demands for highly efficient, atom-economical, and green synthesis. This review summarizes recent advances in the nickel-catalyzed intermolecular asymmetric hydrofunctionalization reactions of alkenes and forecasts the future direction of this field.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
务实的宛完成签到,获得积分10
1秒前
顾矜应助彳亍采纳,获得10
1秒前
1秒前
不吃糖完成签到,获得积分10
2秒前
观鹤轩完成签到 ,获得积分10
2秒前
3秒前
3秒前
Vespa应助俏皮的冷松采纳,获得10
3秒前
小猫咪和小脑斧完成签到,获得积分10
4秒前
5秒前
5秒前
简单山槐完成签到 ,获得积分10
6秒前
7秒前
9秒前
妥妥酱发布了新的文献求助10
9秒前
言雨发布了新的文献求助10
10秒前
12秒前
潘爱玲发布了新的文献求助10
12秒前
科研达人发布了新的文献求助10
12秒前
14秒前
15秒前
今后应助一二三采纳,获得10
15秒前
16秒前
17秒前
17秒前
整齐水杯完成签到,获得积分10
17秒前
18秒前
小盼发布了新的文献求助10
18秒前
cc完成签到,获得积分10
19秒前
20秒前
20秒前
21秒前
小蘑菇应助骄傲的叶凡采纳,获得10
21秒前
23秒前
乙酰唑胺发布了新的文献求助10
23秒前
24秒前
CodeCraft应助123采纳,获得10
25秒前
Akim应助平常竹采纳,获得10
25秒前
26秒前
26秒前
高分求助中
歯科矯正学 第7版(或第5版) 1004
Semiconductor Process Reliability in Practice 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 600
GROUP-THEORY AND POLARIZATION ALGEBRA 500
Mesopotamian divination texts : conversing with the gods : sources from the first millennium BCE 500
Days of Transition. The Parsi Death Rituals(2011) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3234201
求助须知:如何正确求助?哪些是违规求助? 2880628
关于积分的说明 8216151
捐赠科研通 2548179
什么是DOI,文献DOI怎么找? 1377602
科研通“疑难数据库(出版商)”最低求助积分说明 647925
邀请新用户注册赠送积分活动 623302