昼夜节律
生物钟
生物
时钟
癌变
背景(考古学)
基因
细菌昼夜节律
永恒的
振荡基因
癌症
计算生物学
遗传学
神经科学
古生物学
作者
Sara M. Ortega-Campos,Eva M. Verdugo‐Sivianes,Ana Amiama-Roig,José Ramón Blanco,Amancio Carnero
标识
DOI:10.1016/j.bbcan.2023.188900
摘要
The molecular machinery of the circadian clock regulates the expression of many genes and processes in the organism, allowing the adaptation of cellular activities to the daily light-dark cycles. Disruption of the circadian rhythm can lead to various pathologies, including cancer. Thus, disturbance of the normal circadian clock at both genetic and environmental levels has been described as an independent risk factor for cancer. In addition, researchers have proposed that circadian genes may have a tissue-dependent and/or context-dependent role in tumorigenesis and may function both as tumor suppressors and oncogenes. Finally, circadian clock core genes may trigger or at least be involved in different hallmarks of cancer. Hence, expanding the knowledge of the molecular basis of the circadian clock would be helpful to identify new prognostic markers of tumorigenesis and potential therapeutic targets.
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