Recent advances in radical cascade cyclization of 1,n-enynes with trifluoromethylating agents

Cyclic compounds are widely present in natural products, pharmaceuticals, agrichemicals and materials. The development of novel, high efficient and high selective strategies for the synthesis of cyclic compounds has obtained great research interests in organic synthetic field. In past two decades, the free-radical chemistry has been greatly developed than other periods in history, in which the radical cascade cyclizations of 1,n-enynes with trifluoromethyl have emerged as a powerful strategy for the preparation of trifluoromethyl containing carbocycles and heterocycles. In this context, we review the recent advances in the radical cascade cyclization of 1,n-enynes with trifluoromethyl. Furthermore, the detailed reaction mechanisms have also been discussed.