软骨发生
再生(生物学)
自愈水凝胶
软骨
关节软骨修复
细胞生物学
化学
干细胞
软骨细胞
间充质干细胞
间质细胞
药物输送
生物医学工程
生物相容性
关节软骨
解剖
生物
骨关节炎
医学
病理
高分子化学
癌症研究
有机化学
替代医学
作者
Xi Yuan,Junlai Wan,Yang Yang,Long Huang,Chuankun Zhou,J. Su,Shuai‐Bin Hua,Hongxu Pu,Yi Zou,Hao Zhu,Xulin Jiang,Jun Xiao
标识
DOI:10.1016/j.carbpol.2022.120492
摘要
Regeneration of injured articular cartilage is limited by low early-stage recruitment of stem cells and insufficient chondrogenic differentiation. Hydrogels are widely used to repair cartilage because they have excellent mechanical and biological properties. In this study, a dual drug-loaded thermosensitive hydroxypropyl chitin hydrogel (HPCH) system was prepared to release stromal-derived factor-1α-like polypeptides (SDFP) and kartogenin (KGN) for stem-cell recruitment and chondrogenic differentiation. The hydrogel had a network structure that promoted cell growth and nutrient exchange. Moreover, it was temperature sensitive and suitable for filling irregular defects. The system showed good biocompatibility in vitro and promoted stem-cell recruitment and chondrogenic differentiation. Furthermore, it reduced chondrocyte catabolism under inflammatory conditions. Animal experiments demonstrated that the dual-drug hydrogel systems can promote the regeneration of articular cartilage in rats. This study confirmed that an HPCH system loaded with KGN and SDFP could effectively repair articular cartilage defects and represents a viable treatment strategy.
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