线粒体
免疫系统
肝纤维化
细胞
细胞生物学
纤维化
回归
化学
纳米技术
材料科学
癌症研究
医学
生物
免疫学
生物化学
病理
数学
统计
作者
Tingting Che,Xiaopeng Yang,Yuanyuan Zhang,Zheng Yin,Yufei Zhang,Xinge Zhang,Zhongming Wu
出处
期刊:Small
[Wiley]
日期:2024-05-09
被引量:1
标识
DOI:10.1002/smll.202400413
摘要
Liver fibrosis is a coordinated response to tissue injury that is mediated by immune cell interactions. A mitochondria-regulated information-processing (MIP) nanosystem that promotes immune cell communication and interactions to inhibit liver fibrosis is designed. The MIP nanosystem mimics the alkaline amino acid domain of mitochondrial precursor proteins, providing precise targeting of the mitochondria. The MIP nanosystem is driven by light to modulate the mitochondria of hepatic stellate cells, resulting in the release of mitochondrial DNA into the fibrotic microenvironment, as detected by macrophages. By activating the STING signaling pathway, the developed nanosystem-induced macrophage phenotype switches to a reparative subtype (Ly6C
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