APOE ε4 allele modifies the associations of toxic metals and their mixture with cognitive impairment among older adults

载脂蛋白E 内科学 认知 优势比 心理学 基因型 神经心理学 逻辑回归 医学 精神科 遗传学 生物 基因 疾病
作者
Qiang Liu,Junzhe Li,Xuqiu Cheng,Guimei Chen,Yan Zhang,Ziwei Tian,Yuan Wang,Li Wang,Xianwei Guo,Huaibiao Li,Liang Sun,Bing Hu,Shouxin Zhang,Chunmei Liang,Jie Sheng,Fangbiao Tao,Jun Wang,Linsheng Yang
出处
期刊:Environmental Research [Elsevier BV]
卷期号:255: 119148-119148
标识
DOI:10.1016/j.envres.2024.119148
摘要

The evidence of interactive effect of the toxic metal (TM) mixture and apolipoprotein E (APOE) ε4 gene on cognitive impairment in older adults is scarce. We aimed to explore whether the associations of single TMs and their mixture with cognitive impairment depend on APOE ε4 in Chinese community-dwelling older people. A total of 1148 older adults from a subset of the baseline survey of a cohort study were included. Blood arsenic (As), cadmium (Cd), lead (Pb), strontium (Sr), and vanadium (V) were detected by inductively coupled plasma mass spectrometry. APOE gene (rs429358, rs7412) polymorphisms were analyzed by the Polymerase Chain Reaction instrument. Mixed effects logistic regression was applied to estimate the relationships of single TMs and APOE genotype with cognitive impairment. Weighted Quantile Sum (WQS) and Bayesian kernel machine regression (BKMR) models were performed to examine joint impacts of the TM mixture, as well as the interaction of the TM mixture with APOE ε4 genotype on cognitive impairment. Pb displayed a significant linear association with an increased odds of cognitive impairment after adjustment for covariates (Ptrend = 0.045). While APOE genotype did not show a significant correlation with cognitive impairment. WQS showed that the TM mixture was associated with an increased risk of cognitive impairment by 31.0% (OR=1.31, 95% CI: 0.92, 1.87) while no significance was found. BKMR exhibited a significant linear association between the TM mixture and cognitive impairment. Moreover, both WQS and BKMR indicated that Pb contributed the most to cognitive impairment within the mixture. Significant interactions of Pb or the TM mixture and APOE genotype on cognitive impairment were observed, contributing to 38.1% and 38.2% of total effects, respectively. APOE ε4 allele amplifies the associations of single Pb or the TM mixture with cognitive impairment. These findings may help to develop precision prevention.
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