低氧血症
缺氧(环境)
医学
反射
阻塞性睡眠呼吸暂停
刺激(心理学)
心脏病学
内科学
睡眠呼吸暂停
病理生理学
心理学
化学
有机化学
氧气
心理治疗师
作者
Brooke M. Shafer,Christopher R. West,Glen E. Foster
出处
期刊:American Journal of Physiology-regulatory Integrative and Comparative Physiology
[American Physiological Society]
日期:2024-05-13
卷期号:327 (1): R1-R13
标识
DOI:10.1152/ajpregu.00237.2023
摘要
Hypoxia is a pivotal factor in the pathophysiology of various clinical conditions, including obstructive sleep apnea, which has a strong association with cardiovascular diseases like hypertension, posing significant health risks. Although the precise mechanisms linking hypoxemia-associated clinical conditions with hypertension remains incompletely understood, compelling evidence suggests that hypoxia induces plasticity of the neurocirculatory control system. Despite variations in experimental designs and the severity, frequency, and duration of hypoxia exposure, evidence from animal and human models consistently demonstrates the robust effects of hypoxemia in triggering reflex-mediated sympathetic activation. Both acute and chronic hypoxia alters neurocirculatory regulation and, in some circumstances, leads to sympathetic outflow and elevated blood pressures that persist beyond the hypoxic stimulus. Dysregulation of autonomic control could lead to adverse cardiovascular outcomes and increase the risk of developing hypertension.
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