肺炎克雷伯菌
芳基
化学
大肠杆菌
吩噻嗪
金黄色葡萄球菌
结核分枝杆菌
氧化还原
组合化学
立体化学
有机化学
细菌
生物化学
肺结核
生物
烷基
医学
遗传学
病理
药理学
基因
作者
Hilla Khelwati,Lasse van Geelen,Rainer Kalscheuer,Thomas J. J. Müller
出处
期刊:Molecules
[MDPI AG]
日期:2024-05-03
卷期号:29 (9): 2126-2126
标识
DOI:10.3390/molecules29092126
摘要
In this study, a library of 3,7-di(hetero)aryl-substituted 10-(3-trimethylammoniumpropyl)10H-phenothiazine salts is prepared. These title compounds and their precursors are reversible redox systems with tunable potentials. The Hammett correlation gives a very good correlation of the first oxidation potentials with σp parameters. Furthermore, the title compounds and their precursors are blue to green-blue emissive. Screening of the salts reveals for some derivatives a distinct inhibition of several pathogenic bacterial strains (Mycobacterium tuberculosis, Staphylococcus aureus, Escherichia coli, Aconetobacter baumannii, and Klebsiella pneumoniae) in the lower micromolar range.
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