肝损伤
医学
药品
药物管制
药理学
重症监护医学
作者
Antonio Segovia-Zafra,Marina Villanueva-Paz,A.S. Serras,Gonzalo Matilla‐Cabello,Ana Bodoque-García,Daniel E. Di Zeo-Sánchez,Hao Niu,Ismael Álvarez‐Álvarez,Laura Sanz‐Villanueva,Sergej Godec,Irina Milisav,Pierre Bagnaninchi,Raúl J. Andrade,M. Isabel Lucena,José C. Fernández-Checa,Francisco Javier Cubero,Joana P. Miranda,Leonard J. Nelson
标识
DOI:10.1016/j.jhep.2024.04.026
摘要
Idiosyncratic drug-induced liver injury (DILI) is a complex and unpredictable event caused by drugs, and herbal or dietary supplements. Early identification of human hepatotoxicity at preclinical stages remains a major challenge, in which the selection of validated in vitro systems and test drugs has a significant impact. In this systematic review, we analyzed the compounds used in hepatotoxicity assays and established a list of DILI-positive and -negative control drugs for validation of in vitro models of DILI, supported by literature and clinical evidence and endorsed by an expert committee from the COST Action ProEuroDILI Network (CA17112).
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